The present paper predominantly focuses on the different approaches related to the definition of organized crime, the primary conditions that create a convenient foundation upon which organized crime can develop, the main activities of organized criminal groups, and leading organized criminal formations across the different regions of the world, in particular, the Italian Mafia, the Japanese bōryokudan (Yakuza), Chinese triads, Colombian drug cartels, and Russian criminal organizations (“Russian Mafia”), and so on. The second part of the paper is dedicated to the review of the international experience of fighting against transnational organized crime, particularly with regard to different international conventions and agreements within the nineteenth century and first half of the twentieth century. It also explores this phenomena on a UN-level and with reference to a range of European institutions (the EU, Council of Europe). The concluding section sees an examination of the role of law enforcement agencies in the fight against organized crime.