This article presents the reaction of the East-central European (ECE) countries, members of the EU and NATO, to the Coronavirus pandemic. Understandably, there are major similarities as the pandemic—a global challenge—hit every state of the region, by and large, in the same way. The geographical location, size (absence of great powers) and historical traditions led to the exposure of these countries to the pandemic being closely aligned. The points of international reference of these small and medium-sized countries can be seen to align in different directions as to which other states they watch and often follow when deciding about their steps in such a global crisis. This article cannot be fully comprehensive and will, therefore, focus on the reactions of health and emergency services. It raises the question as to whether any similarities are deterministic or whether there are noticeable differences due to the variety of their political systems and current history.